Bioinformatics and Functional Genomics (3rd Ed)
By Jonathan Pevsner
Wiley-Blackwell | October 2015 | ISBN-10: 1118581784 | 1160 pages | PDF | 45.3 mb
https://www.amazon.com/Bioinformatics-Functional-Genomics-Jonathan-Pevsner/dp/1118581784
The bestselling introduction to bioinformatics and genomics – now in its third edition
Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.
This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:
- Extensive revisions and a slight reorder of chapters for a more effective organization
- A brand new chapter on next-generation sequencing
- An expanded companion website, also updated as and when new information becomes available
- Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities
The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software.
This book serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.
About the Author
Jonathan Pevsner, PhD, is a Professor in the Department of Neurology at Kennedy Krieger Institute, an internationally recognized institution dedicated to improving the lives of children with neurodevelopmental disorders. He holds a primary faculty appointment as Professor in the Department of Psychiatry and Behavioral Sciences (Johns Hopkins University School of Medicine). He has taught bioinformatics courses since 2000 at the Johns Hopkins School of Medicine, and was awarded Teacher of the Year honors by the Graduate Student Association in both 2001 and 2006, the Professors’ Award for Excellence in Teaching awarded by the medical faculty (2003), Teacher of the Year (Advanced Academic Programs, 2009), and Teaching Excellence Award in the Johns Hopkins Bloomberg School of Public Health (2011). In 2013 his lab used whole genome sequencing and reported a mutation that causes a rare disease, Sturge-Weber syndrome, as well as a commonly occurring port-wine stain birthmark.
CONTENTS
part I Analyzing DNA, RNA, and Protein Sequences
1 Introduction, 3
2 Access to Sequence Data and Related Information, 19
3 Pairwise Sequence Alignment, 69
4 Basic Local Alignment Search Tool (BLAST), 121
5 Advanced Database Searching, 167
6 Multiple Sequence Alignment, 205
7 Molecular Phylogeny and Evolution, 245
Part II Genomewide Analysis of DNA, RNA, and Protein
8 DNA: The Eukaryotic Chromosome, 307
9 Analysis of Next-Generation Sequence Data, 377
10 Bioinformatic Approaches to Ribonucleic Acid (RNA), 433
11 Gene Expression: Microarray and RNA-seq Data Analysis, 479
12 Protein Analysis and Proteomics, 539
13 Protein Structure, 589
14 Functional Genomics, 635
Part III Genome Analysis
15 Genomes Across the Tree of Life, 699
16 Completed Genomes: Viruses, 755
17 Completed Genomes: Bacteria and Archaea, 797
18 Eukaryotic Genomes: Fungi, 847
19 Eukaryotic Genomes: From Parasites to Primates, 887
20 Human Genome, 957
21 Human Disease, 1011
GLOSSARY, 1075
Self-Test Quiz: Solutions, 1103
Author Index, 1105
Subject Index, 1109
